Windows of Influence: Investigating the Impact of Early Life Factors on Gut Microbiome Development and Autism Risk

Keizer, Roos (2025) Windows of Influence: Investigating the Impact of Early Life Factors on Gut Microbiome Development and Autism Risk. Bachelor's Thesis, Biology.

Preview	Text bBIO2025KeizerRMC.pdf Download (871kB) | Preview
	Text Toestemming.pdf Restricted to Registered users only Download (173kB)

Abstract

Autism Spectrum Disorder (ASD) is a condition characterized by repetitive behaviours and communication impairments. While genetic factors contribute to its aetiology, environmental factors also play a significant role. Individuals with ASD exhibit a distinct gut microbiota, with an altered Bacteroidetes/Firmicutes ratio and a decreased abundance of Bifidobacteria. These findings highlight the importance of the gut-brain axis, as gut dysbiosis can affect neurodevelopment. Conversely, it's also possible that specific behaviors linked to ASD can lead to an altered gut microbiota, which gives rise to the paradoxical relationship between the gut and ASD. This review aims to investigate which early life factors affect the gut microbiome, and when and how they influence the development of ASD. The results suggests that an interplay between different pre-, peri-, and postnatal factors can result in gut dysbiosis, and therefore add to ASD risk. Gut bacteria that are affected by these factors include Bifidobacteria, Lactobacillus and Clostridium. Besides, it appeared that especially mode of delivery is an important factor for the establishment of a healthy gut and normal neurodevelopment. Investigating the exact timeframe in which these factors influence the gut microbiota, could facilitate early life interventions. In this way, the gut microbiota of infants can be restored, which could prevent ASD from developing.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Drion, C.M.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	04 Feb 2025 10:32
Last Modified:	04 Feb 2025 10:32
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/34625

Actions (login required)

View Item