Dual Tracer PET Separation: [⁸⁹Zr]atezolizumab and [¹⁸F]FDG

Vazquez Quiroga, Alesia (2025) Dual Tracer PET Separation: [⁸⁹Zr]atezolizumab and [¹⁸F]FDG. Bachelor's Thesis, Biomedical Engineering.

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Abstract

Dual-tracer Positron Emission Tomography (PET) enables simultaneous imaging of multiple biological processes, providing improved consistency in physiological and pathological conditions. This study compares two signal separation methods– Extrapolation method (EM) and Background Correction (BC) method for signal separation of 89-Zirconium ([⁸⁹Zr])-atezolizumab and [18F]2-fluoro-2-deoxy-D-glucose ([¹⁸F]FDG). One patient’s [⁸⁹Zr]atezolizumab and dual-tracer scans were used to create noiseless phantoms and simulate ten noise realizations. Tracer separation was performed using both methods and evaluated by various statistical measures using both 10-minute and 30-minute simulated [⁸⁹Zr]atezolizumab acquisitions. Statistical analyses included normalized root mean square error (NRMSE) for voxel-level comparisons, and standard deviation (SD) versus bias plots and Bland-Altman analyses for ROI-level assessments. Results showed that the 30-minute scan reduced bias in tumor regions for both methods. The EM method outperformed BC in tumor separation, while BC performed better in non-tumor regions, particularly at the voxel level. These findings support the feasibility of dual-tracer separation but highlight the need for larger sample sizes to strengthen statistical power and support clinical translation.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Tsoumpas, C. and Greuter, M.J.W.
Degree programme:	Biomedical Engineering
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	04 Jul 2025 07:48
Last Modified:	04 Jul 2025 07:48
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/35712

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