Nieuwenhuis, Marjo (2021) Development and implementation of a travelling wave ion mobility spectrometry stage. Master's Thesis / Essay, Applied Physics.
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Abstract
Mass spectrometry is a widely used technique in which ions are discriminated according to their mass-to-charge ratio, but its inability to distinguish different conformations with identical m/q presents a significant weak point. Herein the development of a travelling wave Ion Mobility Spectrometry (TW-IMS) stage to be added to an existing home-built tandemmass spectrometer system is reported. This stage uses the Structures for Lossless Ion Manipulations (SLIM) technique, where the propagation speed of ions through the device is determined by dynamic local electric fields caused by travelling voltage waves, together with collisions with He buffer gas molecules. The array of electrodes that provides the travelling wave field is patterned on printed circuit boards. The drift velocity is related to the collisional cross section and, therefore,to the molecular conformation. Depending on this relation, i.e. their mobility, ions may or may not keep up with the voltage wave. Thus, mobility separation is based on differences in arrival times at the end of the board. This technique allows the usage of long ion paths with minimum losses, resulting in good mobility resolution.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Schlatholter, T.A. |
| Degree programme: | Applied Physics |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 04 May 2021 12:15 |
| Last Modified: | 04 May 2021 12:15 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/24348 |
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